Five Labs Tested Psilocybin’s Lasting Effects. The Mice Had Other Ideas.
In a new five-lab Nature Neuroscience study, psilocybin reliably changed mice in the moment—but several lasting effects failed to replicate. Here’s what that…
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Exploring DMT
Chemistry, reports of entities and the boundaries between experience and interpretation.
- 2 min readDMT: A Clear Introduction to the “Spirit Molecule”
- 2 min readDMT Entities: Machine Elves, Jesters and the Strangest Repeating Cast in Psychedelia
- 2 min read5-MeO-DMT and the “God Molecule”: What It Is and Why the Mythology Got So Big
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43 published articles matching your selection.
LSD and Psilocybin Aren’t Twins. A New Brain-Scan Study Shows Why.
Researchers found LSD and psilocybin affected brain blood flow and connectivity in different directions. The finding is intriguing, but the LSD sample included…
A Short Psychedelic Trip, Weeks of Relief? What the New 5-MeO-DMT Trial Really Shows
A JAMA trial found that one supervised dose of 5-MeO-DMT nasal spray improved depression ratings for some participants. The two-hour headline needs context.
A New Safety Study Cuts Through Psychedelic Hype — Without Proving What the Headlines Might Claim
A new nationally weighted survey found meaningful self-reported adverse outcomes among recent psychedelic users. It also cannot prove that the drugs caused those…
Psychedelic Research Is Leaving the Lab. That Could Make the Data Messier — and More Useful
Controlled trials are good at reducing mess. Real psychedelic use is mostly mess. A new UCSF project wants to study what happens when…
The Brain on Psilocybin Is Not Just “More Chaotic”: What New Research Says About Context
“Psychedelics make the brain more chaotic” is a neat headline. A large 2026 imaging study suggests the reality is more structured — and…
Psychedelic Medicine Has Entered the Boring Part. That’s Probably Good News.
COMP360 Phase 3 results, FDA psychedelic guidance and new therapist-training infrastructure all point to the same shift: psychedelic medicine is moving from proving…
Psilocybin Has Reached Phase 3. Here’s What COMPASS’s Results Actually Mean
COMPASS Pathways now has two positive pivotal Phase 3 trials of COMP360 psilocybin for treatment-resistant depression. Here is what the results actually mean—and…
The FDA Is Building a Rulebook for Psychedelics. What Actually Changed in 2026
The FDA now has final guidance written specifically for psychedelic-drug trials. That is important. It is also very easy to overstate what it…
Ayahuasca vs. Psilocybin: Similar Mystique, Different Chemistry and Context
Updated September 2026. This article is educational and is not medical or legal advice.Psychedelic culture has a talent for turning an interesting observation…
Psychedelics in End-of-Life and Palliative Care: Meaning When Time Is Short
Updated September 2026. This article is educational and is not medical or legal advice.Here is the useful version, without the incense-cloud certainty: Some…
Psychedelics and OCD: What the Research Can—and Cannot—Tell Us
Updated September 2026. This article is educational and is not medical or legal advice.Psychedelic culture has a talent for turning an interesting observation…
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