Five Labs Tested Psilocybin’s Lasting Effects. The Mice Had Other Ideas.

Five Labs Tested Psilocybin’s Lasting Effects. The Mice Had Other Ideas.

PSYCHONAUTDREAM · RESEARCH / PSYCHEDELIC SCIENCE · NOVEMBER 2, 2026 There is a particular kind of psychedelic headline that arrives already wearing a halo: a single dose, a transformed brain, a lasting change. It makes for irresistible reading. It also gives scientists a fairly large problem when somebody else tries to run the experiment. Today, Nature Neuroscience published a study…

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LSD and Psilocybin Aren’t Twins. A New Brain-Scan Study Shows Why.

LSD and Psilocybin Aren’t Twins. A New Brain-Scan Study Shows Why.

Research & context · October 31, 2026 We’ve gotten used to talking about LSD and psilocybin as if they’re variations on the same theme. Both are classic psychedelics. Both act on serotonin receptors. Both can produce startling changes in perception, emotion, and a person’s sense of self. But underneath those similarities, the brain may be doing quite different things. In…

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A Short Psychedelic Trip, Weeks of Relief? What the New 5-MeO-DMT Trial Really Shows

A Short Psychedelic Trip, Weeks of Relief? What the New 5-MeO-DMT Trial Really Shows

Updated October 31, 2026 · Research & context There’s a very unglamorous problem with psychedelic therapy: somebody has to book the room. Long sessions don’t just ask patients to clear their calendars. They require trained staff, monitoring, space, and a way to pay for all of it. A promising treatment that’s too expensive or difficult to deliver can stay out…

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A New Safety Study Cuts Through Psychedelic Hype — Without Proving What the Headlines Might Claim

Psychedelic safety discourse has two favorite settings: “basically harmless” and “obviously dangerous.” Reality, as usual, has declined the invitation to become a slogan. A study published September 29, 2026 in JAMA Network Open examined self-reported adverse health outcomes among U.S. adults who had recently used psilocybin, LSD, MDMA, ibogaine or 5-MeO-DMT. It is useful because controlled clinical trials do not…

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The Surrealist Book Was Never Just a Book

The book that refused to behave A normal book is an efficient little machine. Open cover, turn page, read words, repeat until the author has finished telling you what to think. The Surrealists looked at that arrangement and wondered what would happen if the machine started dreaming in public. At New York’s Museum of Modern Art, The Surrealist Book: Tomorrow…

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How to Look at Psychedelic Art Without Calling Everything “Trippy”

“Trippy” is useful in the same way “tasty” is useful at a restaurant. It communicates a reaction. It does not give us much to work with. Psychedelic art deserves better verbs. You do not need an art-history degree, a pharmacology background or a scarf collection of suspicious size to look at psychedelic art seriously. You need questions that move past…

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Psychedelic Research Is Leaving the Lab. That Could Make the Data Messier — and More Useful

Science loves control because reality is badly behaved. A clinical trial can standardize dose, screening, timing, environment and measurement. That is precisely why clinical trials are useful. They reduce the number of things that can explain an outcome. Most psychedelic use, unfortunately for tidy diagrams, does not occur inside a clinical trial. That gap is the premise of a new…

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The Brain on Psilocybin Is Not Just “More Chaotic”: What New Research Says About Context

Psychedelic neuroscience has accumulated a collection of irresistible phrases: increased entropy, network disintegration, flattened landscapes, relaxed beliefs, criticality. They are useful. They are also extremely easy to turn into the scientific equivalent of a lava lamp. A major 2026 psilocybin study in Nature complicates one of the most popular simplifications: that the psychedelic brain is mainly becoming more disordered. The…

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