Five Labs Tested Psilocybin’s Lasting Effects. The Mice Had Other Ideas.
In a new five-lab Nature Neuroscience study, psilocybin reliably changed mice in the moment—but several lasting effects failed to replicate. Here’s what that…
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Psychedelic Science
Start with how the brain works, then compare recent research, replication and unresolved questions. Correlation is not proof of mechanism.
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The Neuroscience of Psychedelics: What We Know Beyond the Brain-Scan Fireworks2 min readHow Psilocybin Works: From Serotonin Receptors to Strange Meaning2 min readPsychedelic Research Is Leaving the Lab. That Could Make the Data Messier — and More Useful3 min read
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What can brain scans actually tell us?
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When does promising research become reliable evidence?
Read clinical updates alongside critical examinations of study design and replication.
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Five Labs Tested Psilocybin’s Lasting Effects. The Mice Had Other Ideas.8 min readLSD and Psilocybin Aren’t Twins. A New Brain-Scan Study Shows Why.7 min readA Short Psychedelic Trip, Weeks of Relief? What the New 5-MeO-DMT Trial Really Shows7 min read
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A Short Psychedelic Trip, Weeks of Relief? What the New 5-MeO-DMT Trial Really Shows7 min readA New Safety Study Cuts Through Psychedelic Hype — Without Proving What the Headlines Might Claim4 min readThe Ethics of Psychedelic Research: Consent, Hype, Power and Who Gets Left Out2 min read
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Five Labs Tested Psilocybin’s Lasting Effects. The Mice Had Other Ideas.8 min readMusic in Psychedelic Therapy: How Sound Shapes the Experience10 min read
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43 published articles matching your selection.
LSD and Psilocybin Aren’t Twins. A New Brain-Scan Study Shows Why.
Researchers found LSD and psilocybin affected brain blood flow and connectivity in different directions. The finding is intriguing, but the LSD sample included…
A Short Psychedelic Trip, Weeks of Relief? What the New 5-MeO-DMT Trial Really Shows
A JAMA trial found that one supervised dose of 5-MeO-DMT nasal spray improved depression ratings for some participants. The two-hour headline needs context.
A New Safety Study Cuts Through Psychedelic Hype — Without Proving What the Headlines Might Claim
A new nationally weighted survey found meaningful self-reported adverse outcomes among recent psychedelic users. It also cannot prove that the drugs caused those…
Psychedelic Research Is Leaving the Lab. That Could Make the Data Messier — and More Useful
Controlled trials are good at reducing mess. Real psychedelic use is mostly mess. A new UCSF project wants to study what happens when…
The Brain on Psilocybin Is Not Just “More Chaotic”: What New Research Says About Context
“Psychedelics make the brain more chaotic” is a neat headline. A large 2026 imaging study suggests the reality is more structured — and…
Psychedelic Medicine Has Entered the Boring Part. That’s Probably Good News.
COMP360 Phase 3 results, FDA psychedelic guidance and new therapist-training infrastructure all point to the same shift: psychedelic medicine is moving from proving…
Psilocybin Has Reached Phase 3. Here’s What COMPASS’s Results Actually Mean
COMPASS Pathways now has two positive pivotal Phase 3 trials of COMP360 psilocybin for treatment-resistant depression. Here is what the results actually mean—and…
The FDA Is Building a Rulebook for Psychedelics. What Actually Changed in 2026
The FDA now has final guidance written specifically for psychedelic-drug trials. That is important. It is also very easy to overstate what it…
Ayahuasca vs. Psilocybin: Similar Mystique, Different Chemistry and Context
Updated September 2026. This article is educational and is not medical or legal advice.Psychedelic culture has a talent for turning an interesting observation…
Psychedelics in End-of-Life and Palliative Care: Meaning When Time Is Short
Updated September 2026. This article is educational and is not medical or legal advice.Here is the useful version, without the incense-cloud certainty: Some…
Psychedelics and OCD: What the Research Can—and Cannot—Tell Us
Updated September 2026. This article is educational and is not medical or legal advice.Psychedelic culture has a talent for turning an interesting observation…
Start a Reading Journey
Curated connections, not just chronological posts.
Reading Journey
Understanding Consciousness
Begin with altered states, then examine selfhood, neuroscience and mystical experience.
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The Science of Psilocybin
Mechanism, brain imaging, clinical evidence and the importance of replication.
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Psychedelic Art Through History
A tour from visual traditions and symbolism to modern curation and the museum.
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Exploring DMT
Chemistry, reports of entities and the boundaries between experience and interpretation.
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Psychedelics: Evidence and Hype
How to separate intriguing results, missing evidence and overstated headlines.
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The Handoff Myth
Four field notes in their original editorial order.
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