by Raul Lopez | Aug 30, 2024 | blog
Most people tend to think that psychedelics are obscure, found only in shady places and used by shady people…oooohh drugs, bad! The reality however is a bit different, I thought it would be fun to put together a list of very well known people that have used psychedelics and had something positive to say. I will also be putting together a list of famous people throughout history that dabbled in psychedelics, in any case I hope you enjoy these!
- Joe Rogan
Joe Rogan, host of “The Joe Rogan Experience,” has become a prominent figure in advocating for the use of psychedelics. He frequently discusses his experiences with substances like DMT (Dimethyltryptamine), psilocybin mushrooms, and ayahuasca on his podcast, emphasizing the profound impact they’ve had on his mental, spiritual, and creative life. Rogan believes psychedelics can help unlock new perspectives and contribute to personal growth.
- Miley Cyrus
Pop star Miley Cyrus has been open about her experiences with ayahuasca, a powerful psychedelic brew from the Amazon. She has described these experiences as life-changing, helping her reconnect with herself and achieve a deeper understanding of her place in the world. Cyrus views psychedelics as a tool for spiritual and emotional healing.
- Mike Tyson
The former heavyweight boxing champion has spoken candidly about his use of psychedelics, including psilocybin mushrooms and 5-MeO-DMT (toad venom). Tyson credits these substances with helping him overcome personal trauma, achieve mental clarity, and foster personal growth. He often shares how psychedelics have helped him gain a new perspective on life and his past.
- Megan Fox
Actress Megan Fox has shared her experiences with ayahuasca, stating that it was one of the most transformative experiences of her life. Fox has credited the psychedelic brew with helping her confront deep emotional issues and gain spiritual insights that have profoundly impacted her outlook on life.
- Will Smith
In his memoir “Will,” the actor revealed his use of ayahuasca, detailing how it helped him confront and overcome his deepest fears. Smith has described the experience as a crucial part of his journey towards personal growth, emotional healing, and spiritual enlightenment.
- A$AP Rocky
Rapper A$AP Rocky has been open about his use of LSD, which he says has enhanced his creativity and allowed him to explore different aspects of his mind. His psychedelic experiences have influenced his music and artistic expression, with references to LSD appearing in his lyrics and visual art.
- Chelsea Handler
Comedian and television host Chelsea Handler has explored various psychedelics, including ayahuasca and psilocybin mushrooms. Handler has discussed how these experiences have helped her gain insights into herself, improve her mental health, and enhance her overall well-being. She often advocates for the therapeutic potential of psychedelics.
- Jim Carrey
While not as explicit as some others, actor Jim Carrey has alluded to his use of psychedelics, particularly in the context of his spiritual exploration. Carrey has discussed how these substances have influenced his understanding of reality, consciousness, and the nature of existence, contributing to his philosophical outlook.
- Tim Ferriss
Author and entrepreneur Tim Ferriss is a strong advocate for the therapeutic use of psychedelics. Ferriss has personally used substances like psilocybin and LSD and has funded research into their potential benefits for treating mental health issues like depression and PTSD. He frequently discusses the impact of psychedelics on creativity, emotional healing, and personal growth.
- Jaden Smith
Jaden Smith, actor and musician, has mentioned using psychedelics such as mushrooms to enhance his creativity and gain deeper insights into life. Smith, who is known for his philosophical musings and artistic explorations, sees psychedelics as a tool for expanding consciousness and exploring the boundaries of creativity.
- Kanye West
While Kanye West hasn’t gone into great detail, he has hinted at using psychedelics, particularly during his creative processes. West’s music and public statements often reflect themes of altered consciousness, suggesting that psychedelics may have played a role in shaping his visionary ideas and innovative approach to art and music.
- Cara Delevingne
Model and actress Cara Delevingne has spoken about her use of psychedelics, particularly as part of her journey toward self-discovery and healing from past traumas. Delevingne views psychedelics as a means of exploring her inner world and finding peace with her identity.
- Kristen Bell
Actress Kristen Bell has openly discussed her positive experiences with psychedelics, particularly in managing depression and anxiety. Bell advocates for the use of psychedelics in mental health care, sharing how these substances have helped her achieve emotional balance and a greater sense of well-being.
- Sarah Silverman
Comedian Sarah Silverman has used psychedelics both recreationally and therapeutically, often highlighting their potential to open the mind and provide profound personal insights. Silverman’s experiences with psychedelics have influenced her outlook on life, creativity, and her comedic style.
- Elon Musk
The entrepreneur and CEO of SpaceX and Tesla has hinted at his use of psychedelics in interviews and on social media, suggesting that these substances may play a role in his visionary thinking and approach to problem-solving. While Musk hasn’t provided specifics, his allusions to psychedelics suggest a curiosity about their potential to expand consciousness.
- Andrew Garfield
The actor has mentioned his experiences with psilocybin mushrooms in interviews, describing them as enlightening and instrumental in understanding himself better. Garfield, known for his introspective nature, credits psychedelics with helping him explore his inner world and navigate complex emotions.
- Sting
Musician Sting has long been an advocate for the use of psychedelics, particularly ayahuasca. He describes these experiences as a means to connect with deeper spiritual realms and achieve personal growth. Sting’s encounters with psychedelics have influenced his music, his spirituality, and his outlook on life.
- Aaron Rodgers
The NFL quarterback recently spoke about his use of ayahuasca, crediting it with improving his mental health and enhancing his performance on the field. Rodgers has described the experience as life-changing and spiritually enlightening, helping him gain clarity and focus in both his personal and professional life.
- Seth Rogen
Known for his advocacy of cannabis, Seth Rogen has also spoken about his experiences with psychedelics. He highlights their potential for creativity and personal insight, often discussing how psychedelics have influenced his comedy and creative projects.
- Joaquin Phoenix
The Oscar-winning actor has alluded to the use of psychedelics in interviews, mentioning their role in his creative process and exploration of complex characters. Phoenix’s intense and transformative performances are often attributed to his deep exploration of consciousness, possibly aided by psychedelics.
- Moby
Musician and activist Moby has credited psychedelics with playing a significant role in his spiritual journey and musical career. He has shared how these substances have helped him explore the depths of his mind and enhance his creative expression.
- John Mayer
The musician has spoken about using LSD and other psychedelics, crediting them with helping him break through creative blocks and explore new musical ideas. Mayer’s experiences with psychedelics have deeply influenced his songwriting and artistic approach.
- Rosie Perez
Actress Rosie Perez has mentioned her positive experiences with psychedelics, particularly in dealing with personal trauma and exploring her spiritual side. Perez has discussed how these experiences have helped her heal and gain a deeper understanding of herself.
- Russell Brand
Comedian and actor Russell Brand has explored psychedelics as part of his recovery journey and spiritual exploration. Brand often discusses the transformative effects psychedelics have had on his worldview, helping him overcome addiction and find meaning in life.
- Sam Harris
Neuroscientist and author Sam Harris has spoken extensively about his experiences with psychedelics, particularly their ability to dissolve the ego and provide profound insights into the nature of consciousness. Harris sees psychedelics as valuable tools for exploring the mind and understanding reality.
- Paul McCartney
Although from an earlier generation, Paul McCartney of The Beatles continues to reflect on the positive influence that psychedelics, particularly LSD, had on his creativity and outlook on life. McCartney’s experiences during the 1960s played a significant role in shaping the band’s music and cultural impact.
- Frances McDormand
The Oscar-winning actress has admitted to trying LSD during her youth and reflected positively on the experience. McDormand has mentioned how psychedelics expanded her perspective and contributed to her artistic and personal growth.
- Taryn Southern
Digital content creator and musician Taryn Southern has used psychedelics to help cope with her cancer diagnosis and find peace. She has shared her journey publicly, discussing how psychedelics have helped her navigate the emotional and existential challenges of living with cancer.
- Kary Mullis
Nobel Prize-winning scientist Kary Mullis, who invented the polymerase chain reaction (PCR) technique, credited his use of LSD with helping him visualize the groundbreaking scientific discovery. Mullis was a vocal advocate for the creative and cognitive benefits of psychedelics.
- Lena Dunham
Actress and writer Lena Dunham has openly discussed her experiences with psychedelics, particularly how they have helped her explore her mental health and creativity. Dunham sees psychedelics as valuable tools for self-discovery and emotional healing.
- Rosie O’Donnell
Comedian and actress Rosie O’Donnell has explored psychedelics as part of her personal growth journey. She has spoken about how these experiences have helped her gain new insights and improve her mental well-being.
- Zoe Kravitz
The actress and singer has alluded to using psychedelics in interviews, especially in the context of self-exploration and personal growth. Kravitz, known for her free-spirited and artistic nature, sees psychedelics as a way to deepen her understanding of herself and the world around her.
- Gwyneth Paltrow
The actress and wellness entrepreneur has featured psychedelics, particularly ayahuasca, on her lifestyle platform Goop. Paltrow has highlighted the spiritual and therapeutic benefits of psychedelics, advocating for their potential in personal transformation and healing.
- Ben Stiller
The actor and director has discussed his psychedelic experiences, particularly how they have influenced his approach to life and creativity. Stiller sees psychedelics as a tool for gaining new perspectives and overcoming mental barriers.
- Marc Maron
Comedian and podcaster Marc Maron has explored psychedelics as part of his journey in understanding life and creativity. Maron often reflects on how these experiences have shaped his comedic style and personal insights.
- Jason Silva
The futurist and filmmaker is a passionate advocate for the mind-expanding effects of psychedelics. Silva frequently discusses how psychedelics have enhanced his creative output and deepened his philosophical inquiries into the nature of consciousness.
- Erykah Badu
The singer has spoken about her use of psychedelics to enhance her spiritual practices. Badu sees these substances as tools for connecting with higher realms of consciousness and exploring the depths of her soul.
- Tommy Chong
The comedian and actor, famous for his stoner persona, has been a long-time advocate for both cannabis and psychedelics. Chong has shared his positive experiences with LSD and other psychedelics, which he believes have broadened his perspective on life.
- Macaulay Culkin
The actor has discussed his use of psychedelics, particularly in the context of personal exploration and insight. Culkin views psychedelics as a way to gain a deeper understanding of his experiences and emotions.
- Anthony Bourdain
The late chef and TV host explored psychedelics during his travels, often reflecting on their impact on his understanding of different cultures and philosophies. Bourdain credited psychedelics with helping him see the world in new and transformative ways.
- Alanis Morissette
The singer-songwriter has credited psychedelics with deepening her emotional and creative life. Morissette has spoken about how these experiences have helped her explore complex emotions and find inspiration for her music.
- Demi Lovato
The singer has been open about using psychedelics to help heal from past trauma and explore her identity. Lovato views psychedelics as a tool for emotional healing and self-discovery.
- Harry Styles
The musician has hinted at using psychedelics, particularly during the creation of his albums. Styles has discussed how these experiences have influenced his music and helped him explore new creative avenues.
- Noel Gallagher
The musician, known for his work with Oasis, has discussed the creative benefits of psychedelics. Gallagher has credited these substances with helping him break through creative blocks and explore new musical directions.
- Daniel Radcliffe
The actor has alluded to his use of psychedelics in interviews, suggesting that these experiences have contributed to his personal growth and artistic exploration.
- Kirsten Dunst
The actress has spoken about her positive experiences with psychedelics, particularly in the context of personal growth and emotional healing. Dunst sees psychedelics as a way to gain insight into her inner world and overcome challenges.
- Evan Rachel Wood
The actress has explored psychedelics as part of her journey toward self-discovery and healing from past traumas. Wood has shared how these experiences have helped her gain a deeper understanding of herself and her emotions.
- Jewel
The singer-songwriter has shared her experiences with psychedelics and how they have impacted her life. Jewel has spoken about using these substances to explore her consciousness and enhance her creativity.
- Duncan Trussell
The comedian and podcaster frequently discusses his positive experiences with psychedelics on his show. Trussell views psychedelics as a tool for exploring the nature of reality and gaining deeper spiritual insights.
- Rick Rubin
The legendary music producer has talked about using psychedelics to inspire creativity and explore new musical ideas. Rubin credits these experiences with helping him produce groundbreaking music across various genres.
- Diplo
The DJ and music producer has explored psychedelics for creativity and self-exploration. Diplo has spoken about how these experiences have influenced his music and allowed him to push creative boundaries.
- Ezra Miller
The actor has mentioned their use of psychedelics for personal and artistic exploration. Miller views psychedelics as a way to deepen their understanding of themselves and their craft.
- Carlos Santana
The legendary guitarist has credited psychedelics with deeply influencing his music and spiritual beliefs. Santana has spoken about how these experiences have helped him connect with the divine and explore new dimensions of his creativity.
- Jim James
The lead singer of My Morning Jacket has discussed the impact of psychedelics on his music and personal growth. James sees these experiences as a way to explore the depths of his mind and enhance his creative output.
- Lorde
The singer has hinted at using psychedelics during her creative process, particularly in the making of her albums. Lorde has discussed how these experiences have helped her explore new artistic directions and express herself more authentically.
- Billie Eilish
The Grammy-winning singer has referenced psychedelic experiences in her music and interviews, suggesting that these substances have influenced her creative process and artistic vision.
- Channing Tatum
The actor has explored psychedelics for personal insight and growth. Tatum has spoken about how these experiences have helped him understand himself better and navigate his emotions.
- Chris Rock
The comedian has discussed using psychedelics to gain new perspectives on life and enhance his creativity. Rock sees these experiences as a way to break through mental barriers and find new inspiration for his work.
- Aubrey Plaza
The actress has mentioned her interest in psychedelics for creative exploration. Plaza views these substances as a way to push the boundaries of her artistic expression and explore new dimensions of her craft.
- Rivers Cuomo
The frontman of Weezer has spoken about the role of psychedelics in his music. Cuomo has discussed how these experiences have helped him explore new creative avenues and break through creative blocks.
- Shia LaBeouf
The actor has explored psychedelics as part of his personal transformation and artistic exploration. LaBeouf has spoken about how these experiences have helped him gain a deeper understanding of himself and his craft.
- Courtney Love
The musician has talked about her experiences with psychedelics in the 1990s, particularly how they influenced her music and personal growth. Love has credited these substances with helping her explore new creative directions.
- A$AP Ferg
The rapper has referenced his experiences with psychedelics in interviews and music. Ferg sees these substances as a way to enhance creativity and explore new artistic ideas.
- Post Malone
The musician has discussed using psychedelics to enhance creativity and explore consciousness. Malone has referenced these experiences in his music, suggesting that they have influenced his artistic vision.
- Johnny Depp
The actor has hinted at using psychedelics during his acting career, particularly in his exploration of complex characters. Depp views these experiences as a way to deepen his understanding of his roles and push the boundaries of his craft.
- Ed Sheeran
The musician has alluded to psychedelic use in his songwriting process, suggesting that these experiences have helped him explore new creative directions and express himself more authentically.
- Bella Thorne
The actress and singer has explored psychedelics for self-discovery and healing. Thorne has spoken about how these experiences have helped her navigate emotional challenges and gain a deeper understanding of herself.
- Zachary Quinto
The actor has discussed the positive effects of psychedelics on his mental health. Quinto views these substances as a way to explore his consciousness and enhance his emotional well-being.
- Adam Levine
The Maroon 5 frontman has hinted at using psychedelics for creativity, particularly in his music-making process. Levine sees these experiences as a way to push creative boundaries and explore new artistic ideas.
- Dave Chappelle
The comedian has mentioned psychedelic use in his stand-up routines, often reflecting on the insights and perspectives gained from these experiences. Chappelle sees psychedelics as a tool for exploring the nature of reality and challenging conventional thinking.
- Natasha Lyonne
The actress has explored psychedelics as part of her recovery and personal growth journey. Lyonne has spoken about how these experiences have helped her gain a deeper understanding of herself and navigate emotional challenges.
- Mitch Hedberg
The late comedian was known for his love of psychedelics, which influenced his surreal comedy style. Hedberg’s experiences with these substances were often reflected in his unique and offbeat humor.
- Rob McElhenney
The actor and creator of “It’s Always Sunny in Philadelphia” has discussed using psychedelics to enhance creativity and explore new ideas for his show. McElhenney views these experiences as a way to break free from conventional thinking and push creative boundaries.
- Kate Hudson
The actress has hinted at her experiences with psychedelics in interviews, particularly in the context of personal growth and self-discovery. Hudson sees psychedelics as a tool for exploring her inner world and gaining new perspectives on life.
- Lena Waithe
The writer and producer has talked about the role of psychedelics in her creative process, particularly in helping her explore new storytelling avenues and gain deeper insights into her work.
- James Franco
The actor and director has alluded to using psychedelics during his artistic explorations, particularly in the context of his experimental film projects. Franco views these experiences as a way to challenge traditional narratives and explore new creative possibilities.
- Olivia Wilde
The actress and director has hinted at using psychedelics for creative inspiration, particularly in her film work. Wilde sees these experiences as a way to explore new artistic directions and push the boundaries of storytelling.
- Ari Shaffir
The comedian and podcaster frequently discusses his positive experiences with psychedelics, particularly in the context of personal growth and spiritual exploration. Shaffir views psychedelics as a tool for gaining deeper insights into life and challenging conventional beliefs.
- Emily Ratajkowski
The model and actress has hinted at exploring psychedelics, particularly in the context of self-discovery and personal growth. Ratajkowski sees these experiences as a way to explore her consciousness and gain new perspectives on her life and career.
- Tyler, The Creator
The rapper and music producer has discussed his use of psychedelics in interviews, particularly in the context of his music-making process. Tyler views these experiences as a way to explore new creative directions and push the boundaries of his art.
- Grimes
The Canadian musician and artist has spoken about the influence of psychedelics on her creative work, particularly in the context of her music and visual art. Grimes views psychedelics as a tool for exploring new artistic ideas and challenging traditional narratives.
- Ben Affleck
The actor and director has hinted at the use of psychedelics for personal insight and growth, particularly in the context of his creative work. Affleck sees these experiences as a way to explore new artistic possibilities and gain deeper insights into his craft.
- Liv Tyler
The actress has mentioned her positive experiences with psychedelics, particularly in the context of personal growth and spiritual exploration. Tyler sees psychedelics as a way to explore her inner world and gain new perspectives on life.
- Dave Grohl
The Foo Fighters frontman has hinted at using psychedelics for creativity, particularly in the context of his music-making process. Grohl views these experiences as a way to explore new musical ideas and push the boundaries of his art.
- Maggie Gyllenhaal
The actress has explored psychedelics for self-discovery and personal growth, particularly in the context of her creative work. Gyllenhaal sees these experiences as a way to gain deeper insights into her craft and explore new artistic possibilities.
- Lil Nas X
The rapper has referenced psychedelic experiences in his music and public statements, particularly in the context of his creative process. Lil Nas X views psychedelics as a way to explore new artistic directions and challenge conventional narratives.
- Cameron Diaz
The actress has alluded to using psychedelics for spiritual exploration, particularly in the context of her personal growth journey. Diaz views these experiences as a way to explore her inner world and gain new perspectives on life.
- Pharrell Williams
The musician and producer has hinted at his use of psychedelics in interviews, particularly in the context of his creative work. Williams views these experiences as a way to explore new artistic ideas and push the boundaries of his music.
- Elijah Wood
The actor has discussed the benefits of psychedelics for mental health, particularly in the context of his personal growth journey. Wood sees these experiences as a way to explore his consciousness and gain deeper insights into his life and career.
- Alicia Silverstone
The actress has spoken about using psychedelics as part of her wellness routine, particularly in the context of personal growth and self-discovery. Silverstone views these experiences as a way to explore her inner world and gain new perspectives on life.
- Michelle Rodriguez
The actress has shared her experiences with ayahuasca and other psychedelics, particularly in the context of her spiritual exploration and personal growth. Rodriguez views these experiences as a way to explore her consciousness and gain new insights into her life and career.
- Ricky Williams
The former NFL player has been vocal about his use of psychedelics, particularly ayahuasca, in his journey toward healing and self-discovery. Williams credits these experiences with helping him overcome personal challenges and gain a deeper understanding of himself.
- James Cameron
The filmmaker has hinted at the influence of psychedelics on his visionary approach to storytelling, particularly in the creation of his iconic films like “Avatar.” Cameron sees these experiences as a way to explore new creative possibilities and challenge traditional narratives.
- Anne Hathaway
The actress has discussed her interest in psychedelics, particularly in the context of exploring her consciousness and gaining new insights into her craft. Hathaway views these experiences as a way to deepen her understanding of herself and her work.
- Michael Pollan
The author and journalist has written extensively about his experiences with psychedelics, particularly in his book “How to Change Your Mind.” Pollan views psychedelics as a powerful tool for exploring consciousness and gaining new perspectives on life.
- Tim Robbins
The actor and director has spoken about his positive experiences with psychedelics, particularly in the context of personal growth and creative exploration. Robbins views these experiences as a way to gain deeper insights into his life and work.
- Rupert Grint
The “Harry Potter” actor has mentioned his experiences with psychedelics, particularly in the context of self-discovery and personal growth. Grint sees these experiences as a way to explore his consciousness and gain new insights into his life and career.
- Zach Braff
The actor and filmmaker has discussed his use of psychedelics for creative inspiration, particularly in the context of his work in film and television. Braff views these experiences as a way to explore new artistic ideas and push the boundaries of his craft.
- David Duchovny
The actor has alluded to his experiences with psychedelics, particularly in the context of his creative work and personal growth. Duchovny sees these experiences as a way to explore new artistic possibilities and gain deeper insights into his life and career.
I will leave the last one for the next article, another 100 famous people throughout history known to use psychedelics 😉
by Raul Lopez | Jul 9, 2024 | blog
Introduction & Origins of DMT
Dive into DMT — The Spirit Molecule Unlocked
Imagine inhaling once and, in less time than a whispered breath, finding yourself drifting through kaleidoscopic tunnels of light. That’s the hallmark of DMT (N,N‑Dimethyltryptamine), a naturally occurring hallucinogenic compound celebrated for its rapid onset psychedelic effects. From the Amazon vine to the secretions of the Sonoran Desert toad—and even trace amounts in the mammalian brain—DMT has captivated shamans, scientists, and psychonauts for nearly a century.
DMT’s reputation as the “Spirit Molecule” isn’t just hype. It earned that name because of how rapidly it transforms perception: within seconds of inhalation, the world you know gives way to geometric fractals, sentient light beings, and profound encounters that can feel timeless. While other psychedelics offer longer voyages, DMT’s brevity and intensity set it apart.
This deep dive begins with the ancient shamanic traditions that first harnessed DMT, then follows the molecule into early laboratories and modern clinics. We’ll examine the receptor‑level mechanics—from 5‑HT2A receptor activation to sigma‑1 receptor modulation—that drive both its hallucinatory visuals and emerging therapeutic potential. By the end of Part 1, you’ll understand where DMT came from and how such a simple molecule can deliver such a powerful psychedelic experience.
Quick link: Ready to capture your own insights? Check out our psychedelic journals designed for mind‑bending inspiration.
Ancient Wisdom — From Shamanic Brews to Modern Laboratories
Ayahuasca Rituals
For centuries, Amazonian shamans brewed ayahuasca by combining DMT‑rich vines with MAO inhibitors. This tea became a sacred sacrament, delivering psychedelic compound visions, physical purging, and spiritual healing over 4–6 hours. The ceremonial context—chants, drumming, communal support—ensured participants navigated challenging experiences safely and emerged with deep revelations.
Vision Quests & Sacraments
Beyond ayahuasca, indigenous cultures used toad venom extracts or pure plant distillates in rites of passage. These vision quests served as spiritual bridges, forging connections between individual consciousness and ancestral wisdom.
Laboratory Isolation (1931)
Chemist Richard Manske first synthesized DMT in 1931, igniting Western scientific interest. By the 1950s, researchers were administering DMT to rodents as a model of schizophrenia, because its psychoactive effects—fragmented perception and hyperactivity—mirrored certain psychotic symptoms.
The “Spirit Molecule” Revival
In the 1990s, Dr. Rick Strassman’s human trials with healthy volunteers cemented DMT’s modern reputation. His clinical studies recorded intense subjective experiences, vaulting DMT from fringe curiosity to a focal point of the contemporary psychedelic research renaissance.
Did you know? We carry psychedelic art posters inspired by these visionary motifs—perfect for any explorer’s wall.
The Chemistry — Small Molecule, Big Impact
Molecular Structure & Classification
- Formula: C₁₂H₁₆N₂, part of the indole alkaloid family.
- Classification: A potent hallucinogenic compound and psychoactive agent.
Receptor‑Level Mechanics
- 5‑HT2A receptor activation unleashes DMT’s signature visual effects—fractals, tunnels of light, and sentient entities.
- Sigma‑1 receptor modulation supports neuronal plasticity and is tied to emerging antidepressant effects in recent pilot trials (Jones et al., 2020).
These dual pathways create DMT’s unique blend of rapid, intense imagery and potential mood‑lifting benefits.
Pro tip: After exploring these realms, kick back in one of our psychedelic hoodies and let the visuals settle.
Endogenous DMT — Your Brain’s Secret Ally
Trace amounts of DMT occur naturally in the human brain, hinting at roles in dreaming and near‑death states:
- Dream Model: Some scientists hypothesize surges during REM sleep, fueling vivid, story‑like dreams.
- Neuroprotective Agent: Sigma‑1 engagement may bolster neuronal resilience, offering an unexpected layer of brain health benefit.
This endogenous presence suggests DMT’s role extends beyond recreational use—it may be woven into our very experience of consciousness.
Preparing for Your Journey — Safety, Set & Setting
Before diving into the more intense effects in Part 2, follow these guidelines:
- Health Screening
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- Check for cardiovascular issues. DMT’s cardiovascular effects can include transient spikes in blood pressure and heart rate.
- Trusted Environment
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- Choose a calm, comfortable space with a sober sitter or guide.
- Intent & Integration Plan
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- Clarify your purpose. Line up post‑trip journaling to capture fleeting subjective experiences.
Ready? Proceed safely and download our free DMT Safety Checklist to prepare.
Explosive Effects, Healing Potential & Safety Considerations
Explosive Effects, Healing Potential & Safety Considerations
DMT’s reputation as a rapid onset psychedelic stems from how quickly it transforms perception. Whether inhaled, brewed in ayahuasca, or smoked as Changa, DMT delivers a breathtaking psychedelic experience that’s both vivid and concise. In this section, we’ll break down its hallmark hallucinogenic effects, survey emerging therapeutic promise, and outline essential safety measures to navigate these powerful journeys with confidence.
Unleashing the Psychonaut’s Peak Experience
When DMT arrives in your lungs or bloodstream, the world you know vaporizes within seconds. Here’s what to expect:
- Immediate Ego Dissolution
Boundaries between self and environment vanish almost instantly, often described as a sense of cosmic oneness.
- Vivid Visual Effects
Geometric fractals, flowing tunnels of light, and sentient light beings appear with astonishing clarity, driven by 5‑HT2A receptor activation.
- Hyper‑Synesthesia
Colors, sounds, and tactile sensations blend in a kaleidoscope of sensation—your senses merge into one overarching subjective experience.
- Brief Duration
Most freebase vapor sessions peak at 1–3 minutes and subside by five, while ayahuasca ceremonies extend to 4–6 hours when combined with an MAOI. Changa blends sit in the middle with 20–30 minutes of high‑definition visions.
Quick Reference Table: DMT Administration Methods
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Freebase Vapor
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5–10 seconds
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1–3 minutes
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Breakthrough visuals, ego loss
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Ayahuasca Brew
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20–60 minutes
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4–6 hours
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Purging, extended visions
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Changa (Herbal Mix)
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15–30 seconds
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20–30 minutes
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Mellow visuals, introspection
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Therapeutic & Spiritual Applications
Beyond its intensity, modern clinical studies and ancient traditions both point to meaningful healing potential.
Insights from Clinical Studies
- Antidepressant Effects
Small‑scale trials report significant mood boosts within hours of a DMT session—suggesting rapid relief comparable to ketamine but in a condensed timeframe.
- Neuronal Plasticity
Sigma‑1 receptor modulation appears to promote synaptic growth and resilience, laying groundwork for lasting changes in brain connectivity.
- PTSD & Anxiety Relief
Ayahuasca ceremonies have demonstrated reductions in trauma symptoms, hinting that DMT’s hallucinogenic effects can catalyze deep psychological shifts.
Ancient Traditions, Modern Renewal
Indigenous Amazonian healers have long used DMT in ayahuasca rituals for community healing and spiritual insight. Today’s seekers blend that shamanic wisdom with evidence‑based practice—often following ceremonies with reflective journaling in a dedicated psychedelic journal to integrate lessons into daily life.
Safety Profile & Adverse Effects
While DMT is physically non‑toxic in healthy individuals, its potency demands respect. Key risks include:
Cardiovascular Effects
- Elevated Blood Pressure & Heart Rate
DMT’s action at the 5‑HT2A receptor stimulates the sympathetic nervous system, causing transient spikes in heart contractility. Individuals with hypertension or heart conditions should proceed only with medical clearance.
Psychological Risks
- Bad Trips
Intense hallucinogenic compound exposure can provoke panic, anxiety, or existential dread if unprepared.
- Model of Psychosis
Early research used DMT as a model of schizophrenia—in rare cases, those predisposed to psychosis may experience lingering perceptual disturbances.
Best Practices for Safe Use
- Set & Setting: Cultivate a calm, supportive space. Soft lighting, familiar music, and a trusted sitter make a major difference.
- Dose Responsibly: Start low—consider 1 mg freebase for first‑timers—and work up gradually.
- Integration Therapy: Post‑session discussion with a guide or therapist helps process insights and minimize confusion.
Pro Tip: Wear something cozy—our psychedelic hoodies and psychedelic pillows & blankets create a comforting nest for intense journeys.
Integration, Community & Advanced Research Horizons
Integration, Community & Advanced Research Horizons
After the peak fades, the real work begins: integrating profound insights, connecting with fellow explorers, and watching DMT research pave the way for new therapies. This final installment covers practical integration techniques, community resources, and cutting‑edge studies shaping DMT’s future.
Integration & Reflective Practices
Effective integration turns fleeting visionary moments into long‑term growth.
Journaling & Creative Expression
- Capture every detail—colors, entity messages, emotional shifts—in a dedicated psychedelic journal.
- Transform visions into art or music; consider illustrating fractals on a psychedelic art poster as a visual anchor.
Mindfulness & Bodywork
- Combine breathwork, yoga, or somatic exercises to ground residual energy.
- Practice daily meditation to maintain heightened self‑awareness and reinforce neuronal plasticity.
Professional Support
- Seek integration therapy with trained facilitators who understand DMT’s psychoactive effects.
- Join group circles for shared reflection and emotional support.
Building the Psychonaut Community
Sharing experiences amplifies learning and fosters safety.
Online Forums & Resources
- Participate in discussions on r/DMT, PsychonautWiki, and specialized blogs to compare trip reports and comparative study insights.
- Access peer‑reviewed articles and clinical studies via MAPS and academic journals for evidence‑based perspectives.
Local Meetups & Ceremonies
- Attend gathering circles where ceremonial music, art, and guided rituals create a supportive environment.
- Explore creative collaborations—live painting or digital NFT drops—celebrating DMT‑inspired motifs.
Advanced Clinical Studies & Future Therapies
DMT research is evolving rapidly, unlocking new therapeutic frontiers.
Neuroimaging & Biomarkers
- fMRI studies in healthy volunteers reveal real‑time brain connectivity shifts driven by 5‑HT2A receptor activation.
- PET scans measuring DMT’s binding kinetics help correlate receptor occupancy with subjective experience intensity.
Next-Gen Therapeutics
- Researchers are developing DMT analogues that engage sigma‑1 receptor pathways to harness antidepressant effects without full hallucinogenic potency.
- Phase II/III trials now compare DMT vs. psilocybin for treatment‑resistant depression and PTSD, focusing on long-term use outcomes.
by Raul Lopez | Jul 4, 2024 | blog
In a groundbreaking fusion of biotechnology and culinary innovation, scientists have successfully bred magic mushrooms with potatoes, resulting in what is being dubbed “trippy chips.” This novel creation combines the psychoactive properties of psilocybin mushrooms with the familiar comfort of potatoes, offering a unique and potentially therapeutic snack. This article delves into the science behind this innovation, its potential benefits, and the broader implications for the field of psychedelics.
The Science Behind Trippy Chips
The creation of trippy chips is a testament to the advances in genetic engineering and mycology. Researchers have managed to integrate the psilocybin-producing genes of magic mushrooms into the DNA of potato plants. This genetic modification allows the potatoes to produce psilocybin, the active compound responsible for the psychedelic effects of magic mushrooms.
Genetic Engineering Process
- Gene Identification and Isolation: The first step involved identifying and isolating the genes responsible for psilocybin production in mushrooms, specifically Psilocybe cubensis, a common species of magic mushrooms.
- Gene Insertion: Using advanced techniques like CRISPR-Cas9, scientists inserted these genes into the DNA of potato plants. This process required precise modifications to ensure that the psilocybin genes functioned properly within the potato’s genetic framework.
- Cultivation and Testing: The genetically modified potatoes were cultivated under controlled conditions. Subsequent tests confirmed the presence of psilocybin in the potato tubers, marking a successful fusion of the two organisms.
Potential Benefits of Trippy Chips
The creation of trippy chips opens up several exciting possibilities, particularly in the realms of mental health and therapeutic applications.
Therapeutic Potential
- Depression and Anxiety: Psilocybin has shown promise in treating depression and anxiety, particularly in cases resistant to conventional treatments. The ease of consuming trippy chips could make psilocybin therapy more accessible.
- Post-Traumatic Stress Disorder (PTSD): There is growing evidence that psilocybin can help alleviate symptoms of PTSD by enabling patients to process traumatic experiences more effectively.
- Mental Health Conditions: The potential to address various mental health conditions through a familiar food product could revolutionize treatment paradigms.
Cognitive and Emotional Benefits
- Mood Enhancement: Psilocybin is known for its ability to enhance mood and induce a state of well-being. Regular consumption of trippy chips in controlled doses could offer a natural way to boost mental health.
- Cognitive Function: Preliminary studies suggest that psilocybin can enhance cognitive function and creativity. Integrating psilocybin into everyday foods like chips could provide subtle cognitive benefits without the need for traditional psychedelic sessions.
Safety and Ethical Considerations
While the potential benefits are significant, there are important safety and ethical considerations to address.
Dosage Control
Ensuring consistent and safe dosages in trippy chips is crucial. Overconsumption could lead to intense and potentially distressing psychedelic experiences. Therefore, rigorous quality control and clear labeling are essential.
Legal and Regulatory Issues
Psilocybin remains a controlled substance in many parts of the world. The integration of psilocybin into food products will require careful navigation of legal and regulatory landscapes to ensure compliance and safety.
Ethical Implications
The creation of genetically modified organisms (GMOs) continues to spark ethical debates. Transparency about the genetic modifications and their purposes is vital to maintaining public trust and addressing any concerns.
Broader Implications for Psychedelic Research
The development of trippy chips signifies a broader trend in psychedelic research and its applications. It highlights the potential to integrate psychedelics into everyday life in ways that are safe, controlled, and beneficial.
Integration with Psychedelic-Assisted Therapy
Trippy chips could become a valuable tool in psychedelic-assisted therapy, offering a more palatable and less intimidating option for patients new to psychedelics. They could be used as an adjunct to traditional therapeutic sessions, enhancing the overall therapeutic experience.
Research and Development
The success of trippy chips could spur further research into other potential food-based delivery systems for psychedelics. This could include beverages, desserts, and other familiar food items, broadening the scope of psychedelic therapy.
Conclusion
The creation of trippy chips by breeding magic mushrooms with potatoes represents a fascinating intersection of biotechnology, mycology, and culinary innovation. This breakthrough offers significant potential for therapeutic applications, particularly in treating mental health conditions such as depression, anxiety, and PTSD. However, it also necessitates careful consideration of safety, legal, and ethical issues.
As research continues, trippy chips may pave the way for new, accessible forms of psychedelic therapy, making the benefits of psilocybin more widely available. This innovation underscores the importance of continued exploration and responsible integration of psychedelics into modern medicine and daily life.
by Raul Lopez | Jul 3, 2024 | blog
In recent years, there has been a growing interest in the therapeutic potential of psychedelic drugs, particularly psilocybin, for treating various mental health conditions. A groundbreaking study has shed light on the optimal doses of psilocybin for managing depression, providing new hope for patients with treatment-resistant depression and other psychiatric disorders.
Understanding Psilocybin and Its Effects
Psilocybin is a naturally occurring psychedelic compound found in certain species of mushrooms, commonly known as magic mushrooms. When ingested, psilocybin is converted into psilocin, which interacts with serotonin receptors in the brain, particularly the 5-HT2A receptor. This interaction leads to a range of effects, including altered perception, mood changes, and cognitive shifts, collectively known as a psychedelic experience.
Therapeutic Potential of Psilocybin
Psilocybin’s therapeutic potential has been the focus of numerous studies. Research has shown that psilocybin can lead to significant reductions in depressive symptoms, anxiety, and post-traumatic stress disorder (PTSD). These effects are often accompanied by mystical experiences and profound shifts in consciousness, which can contribute to the drug’s therapeutic benefits.
The Study: Determining Optimal Psilocybin Doses
The recent study aimed to determine the optimal doses of psilocybin for treating depression. The researchers conducted a series of trials involving patients with treatment-resistant depression. Participants were administered varying doses of psilocybin, and their depressive symptoms were monitored using standardized scales such as the Montgomery-Åsberg Depression Rating Scale (MADRS).
Study Design and Methodology
The study employed a randomized, double-blind, placebo-controlled design. Participants were divided into groups and given different doses of psilocybin, ranging from low to high. Each dosing session was followed by supportive psychotherapy sessions to help integrate the psychedelic experience.
Findings: Therapeutic Efficacy and Optimal Doses
The study found that medium to high doses of psilocybin were most effective in reducing depressive symptoms. Participants reported significant improvements in their mood, outlook on life, and overall mental health. The therapeutic effects were sustained over several weeks, indicating the potential for long-term benefits.
Moreover, the study highlighted the importance of preparatory and integration sessions. These sessions, which involved supportive psychotherapy, were crucial in helping participants process their experiences and maximize the therapeutic benefits of psilocybin.
Benefits and Safety of Psilocybin-Assisted Therapy
Psilocybin-assisted therapy has shown promise in treating various mental health conditions. The benefits include:
- Rapid Reduction in Symptoms: Psilocybin can lead to a rapid decrease in depressive symptoms, often within hours of administration.
- Long-Lasting Effects: The therapeutic effects of psilocybin can last for several weeks or even months.
- Enhanced Emotional Processing: Psilocybin facilitates deep emotional processing, allowing patients to confront and resolve underlying issues.
- Improved Quality of Life: Patients report an overall improvement in their quality of life, including better relationships and increased motivation.
Safety Considerations
While psilocybin has shown promise, it is essential to consider safety. The study monitored participants for adverse effects, such as anxiety, paranoia, and psychotic symptoms. These effects were generally mild and transient, but they highlight the need for careful screening and monitoring.
The Role of Psychedelic-Assisted Psychotherapy
Psychedelic-assisted psychotherapy combines the administration of psychedelics with structured therapeutic support. This approach enhances the therapeutic potential of psychedelics and ensures patient safety. The integration of psilocybin into psychotherapy sessions can lead to profound insights and emotional breakthroughs.
The Integration Process
The integration process involves several steps:
- Preparation: Before the dosing session, patients undergo preparatory sessions to set intentions and build trust with their therapist.
- Dosing Session: Patients receive psilocybin in a controlled setting, with therapists providing support throughout the experience.
- Integration: After the session, patients participate in integration sessions to process their experiences and apply insights to their daily lives.
Future Directions and Implications
The study’s findings have significant implications for the future of mental health treatment. Psilocybin’s ability to produce rapid and sustained symptom reduction offers a new avenue for patients who have not responded to conventional treatments.
Potential for Wider Application
Beyond depression, psilocybin shows potential for treating other mental health conditions, including:
- Anxiety Disorders: Psilocybin can reduce anxiety and improve emotional regulation.
- PTSD: Psilocybin-assisted therapy can help patients process traumatic memories and reduce PTSD symptoms.
- Substance Use Disorders: Psilocybin has been shown to reduce cravings and substance use in patients with alcohol and opioid use disorders.
Ongoing Research and Clinical Trials
Ongoing research aims to further understand the mechanisms of psilocybin and optimize its use in clinical settings. Future studies will focus on:
- Long-Term Efficacy: Assessing the long-term benefits and potential risks of psilocybin therapy.
- Mechanisms of Action: Investigating how psilocybin interacts with brain circuits and alters cognitive and emotional processing.
- Personalized Treatment: Identifying factors that influence individual responses to psilocybin and tailoring treatments accordingly.
Conclusion
The study on optimal psilocybin doses for depression represents a significant step forward in psychedelic research. Psilocybin’s ability to produce rapid and lasting reductions in depressive symptoms, combined with its potential to treat other mental health conditions, makes it a promising candidate for widespread clinical use. As research continues, psilocybin-assisted therapy may become a mainstream treatment option, offering hope to millions of patients worldwide.
By adhering to rigorous study designs and ensuring patient safety, researchers can unlock the full therapeutic potential of psilocybin and transform the landscape of mental health care.
by Raul Lopez | Jul 2, 2024 | blog
Microdosing psychedelic mushrooms, particularly psilocybin mushrooms, has gained popularity for its potential mental health benefits. However, there’s a growing trend of “stacking” these microdoses with other supplements to enhance or complement their effects. Here’s a deep dive into the concept of stacking and its potential benefits and risks.
Understanding Microdosing and Stacking
Microdosing involves taking sub-perceptual doses of psychedelics, such as psilocybin mushrooms or LSD (lysergic acid diethylamide). These small doses are intended to improve mood, creativity, focus, and overall well-being without the hallucinogenic effects of a full dose. Stacking refers to combining these microdoses with other supplements, often referred to as nootropics, adaptogens, or vitamins, to potentially amplify their benefits.
Popular Supplements for Stacking
- Lion’s Mane Mushrooms
- Benefits: Known for its neuroprotective and neurogenerative properties, Lion’s Mane is often stacked with psilocybin to enhance cognitive function and potentially support brain health.
- Niacin (Vitamin B3)
- Benefits: Niacin is believed to aid in the distribution of psilocybin throughout the body by promoting blood flow. Some proponents suggest that this can enhance the overall effectiveness of the microdose.
- CBD (Cannabidiol)
- Benefits: Known for its calming effects, CBD can help reduce anxiety and enhance mood stability, making it a popular supplement to stack with microdoses of psychedelics.
- Ashwagandha
- Benefits: As an adaptogen, Ashwagandha helps the body manage stress and improve mental clarity. Stacking it with psychedelics may help balance the stimulating effects of the microdose.
- Bacopa Monnieri
- Benefits: This herb is traditionally used to improve memory and cognitive function, making it a potential complement to the cognitive enhancements sought from microdosing.
Potential Benefits of Stacking
- Enhanced Cognitive Function: Combining microdoses with cognitive-enhancing supplements like Lion’s Mane and Bacopa Monnieri can potentially improve focus, memory, and overall brain function.
- Mood Stabilization: Supplements like CBD and Ashwagandha can help manage anxiety and stress, providing a balanced and stable mood throughout the day.
- Improved Neuroplasticity: Certain stacks may promote neuroplasticity, the brain’s ability to adapt and form new neural connections, which is often a goal of microdosing.
- Potential Benefits for Mental Health Conditions: By stacking microdoses with these supplements, there is potential for greater benefits in treating conditions such as anxiety disorders, depressive disorders, and other psychiatric disorders.
Risks and Considerations
While stacking can offer potential benefits, it’s essential to consider the risks:
- Interactions: Combining different substances can lead to unpredictable interactions. It’s crucial to research and understand how each supplement interacts with others.
- Dosage: Finding the right dosage for each supplement in a stack is vital to avoid adverse effects. Starting with low doses and gradually adjusting is a common practice.
- Legality and Safety: The legal status of psychedelics varies by region, and the safety of combining them with other supplements is not well-studied. Consulting with a healthcare professional before starting any stacking regimen is advisable.
- Potential Negative Side Effects: Although microdosing and stacking are intended to avoid hallucinogenic effects, there may still be adverse effects, including physical effects such as changes in blood pressure, and psychological effects such as increased anxiety.
Observational and Longitudinal Studies
Observational and longitudinal studies on microdosing and stacking are crucial for understanding the long-term effects and potential benefits. These studies can help to identify patterns, efficacy, and safety profiles. For example, research by Zach Walsh and other scientists has shown that stacking can have positive effects on emotional stability and cognitive performance.
Cognitive Function and Performance
One of the most touted benefits of microdosing and stacking is the improvement in cognitive function. Combining microdoses with supplements like Lion’s Mane mushrooms can potentially enhance cognitive performance, providing benefits for daily life and work tasks. Users often report improvements in memory, focus, and overall mental clarity.
Mental Health and Emotional Well-Being
Mental health is a significant area where stacking microdoses with other supplements can have beneficial effects. Supplements like Ashwagandha and CBD can enhance the mood-stabilizing effects of psychedelics, potentially providing more substantial relief from symptoms of depression, anxiety, and other mental health conditions.
Intuitive Microdosing
Intuitive microdosing involves listening to one’s body and adjusting doses and stacks based on individual needs and responses. This personalized approach can help optimize the benefits and reduce the risks associated with stacking.
Potential for Treating Psychiatric Disorders
Microdosing and stacking hold promise for treating various psychiatric disorders, including bipolar disorder and depressive disorders. The therapeutic potential of this approach is being explored in numerous studies, highlighting the need for systematic and rigorous research to establish safety and efficacy.
Future Studies and Research Directions
Future studies on microdosing and stacking should focus on understanding the long-term effects, optimal dosages, and combinations. These studies can provide valuable insights into the benefits and risks, guiding safe and effective practices. Researchers are particularly interested in the effects of different stacks on cognitive function, emotional well-being, and overall mental health.
Conclusion
Stacking microdoses of psychedelics with other supplements can potentially enhance their benefits, but it comes with risks. It’s essential to approach this practice with caution, thorough research, and professional guidance. As interest in microdosing and stacking grows, more research will likely emerge, providing clearer guidelines and safety profiles for those interested in exploring these combinations. The potential benefits for cognitive function, mental health, and emotional well-being make this an exciting area of study, promising new insights and therapeutic options for various mental health conditions.
